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The Saint Louis Tinnitus Study: An Insight
Even though the reminiscences of
“The Spirit of St. Louis” lingers long in the background
of our brains, reminding us of the tiny single engine,
single seat monoplane by that name in which Charles
Lindbergh crossed the Atlantic way back in 1927, it has,
in the present context, very little to do with the
Clinical Research Studies conducted by the Academic
Otolaryngology Clinic in St. Louis.
There are more than 40 million
sufferers from subjective or objective type of tinnitus
in continental America, and
to a large percentage of them it is a curse. Yet, not
unlike shingles, there is hardly any treatment regime
available to these ill fated people, who are in
desperate need of relief in any form whatsoever. No
wonder the FDA refuses to approve any of the so called
sure fire but ridiculously ineffective ‘cures’ for
tinnitus hyped by the television, the press or the
Internet.
However,
it is good to know that the Academic Otolaryngology
Clinic in St.
Louis has embarked upon
conducting clinical research studies on the curative
aspect of tinnitus and that they have published their
views on the topic for the benefit of tinnitus patients,
some of which are highlighted below.
The
Saint Louis
Tinnitus Study - Current
Studies On The Topic Include The Use Of Gobapentin In
Regard To Providing Relief For The Idiopathic Tinnitus
(Subjective) Trial As Per The Following Modes
- Objective: To determine the Gobapentin
(Neurontin) medicinal in
regard to subjective idiopathic
tinnitus.
- Design:
Double-blind eight-week indiscriminate medical
test.
- Location:
St.
Louis Academic Otolaryngology
Clinic.
- Topics:
135 issues with rigorous idiopathic tinnitus
(subjective) of six months, or longer than
that.
- Involvement:
The drug at continuance dosage covering 900 – 3600
mg/day for eight weeks. Lactose placebo may also be
tried.
- Principal
outcome measure: Alteration involving the handicap
inventory score of tinnitus starting from the baseline
to end (study) point.
- General
change in the handicap inventory score for total
cohort from the baseline to the 8th week =
11.2
- Change
involving the 56 people selected at random in regard
to the Gobapentin arm
=11.3
Change
among 56 people in the placebo =
11.00
The
Saint
Louis
Tinnitus Study Conclusion –
The Drug Is Equally Ineffective Like The Placebo In
Regard To Relief From Idiopathic Subjective
Tinnitus
The next study involves the
following
The Saint Louis Tinnitus
Study
– The Academic Otolaryngology
Clinic At St. Louis Concerns With (Rtms) Or Repetitive
Transcranial Magnetic Stimulation To Provide Relief From
Idiopathic Subjective Tinnitus As Detailed
Below
Many
Americans suffer from tinnitus that is chronic
incapacitating subjective while Neuroimaging studies
conducted at random have revealed those to be related to
hyperactivity of sundry cortical areas, particularly the
auditory cortices, plus the middle temporal
regions.
rTMS or
Repetitive Transcranial Magnetic Stimulation entails
application of repeated magnetic spur in the skull which induces an electro-magnetic field within
the brain’s cortical areas that are underlying. However,
with low frequency stimulations (1 Hz), the rTMS tends
to steer to an increased inhibitory activity in regard
to the glutaminergic
fibers of the central nervous system. This
conclusively proves that rTMS is a newly acquired
treatment modality that can be termed as fairly
promising for tinnitus victims.
Nevertheless,
there will be 3 definite plans to provide appropriate
guidance to the project which is detailed below for the
benefit of the reader.
- To
ascertain rTMS’s curative value of subjective
idiopathic troublesome tinnitus, a lone blind-over
fortuitous trial design involving active versus fake
rTMS
would be employed. Enrolment will go up to 55
subjects while the size of samples will tend to ensure
adequate power to evaluate any clinically significant
disparity between the treatments that are defined in
terms of a 20-point alteration of the THI score.
Several neurocgnitive function tests, carried out
before and after the treatment would be done to check
if there were more adverse effects in the rTMS as well
as executive functioning.
- To make
out the predictors and find out the response factor
associated with rTMS treatment for people with acute
tinnitus problem. The hypothesis includes several
patient factors, clinical features, audiological
issues, neurocognitive factors as well as findings in
the PET scan at baseline. Also to be considered are
changes, if any, concerning these mentioned factors
after the rTMS therapy that could be the predictors of
the rTMS response.
- To spot
any phenotype (tinnitus patient) that may respond more
to rTMS.
This research study, as is expected,
will throw valuable light on newer treatment modes for
tinnitus, especially the rTMS which appears to be quite
promising. However, the results will speak for
themselves. But as of now, the best mode of treatment is
to not look at the symptoms
(as is the case with conventional remedies),
but reach out to within the body and identify all the
key contributing factors, which can be many. Once these
contributing factors have been identified, tinnitus can
be effectively treated, and it will never come back
again to haunt you.
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