Tinnitus Guide

The Saint Louis Tinnitus Study: An Insight

Even though the reminiscences of “The Spirit of St. Louis” lingers long in the background of our brains, reminding us of the tiny single engine, single seat monoplane by that name in which Charles Lindbergh crossed the Atlantic way back in 1927, it has, in the present context, very little to do with the Clinical Research Studies conducted by the Academic Otolaryngology Clinic in St. Louis.

There are more than 40 million sufferers from subjective or objective type of tinnitus in continental America, and to a large percentage of them it is a curse. Yet, not unlike shingles, there is hardly any treatment regime available to these ill fated people, who are in desperate need of relief in any form whatsoever. No wonder the FDA refuses to approve any of the so called sure fire but ridiculously ineffective ‘cures’ for tinnitus hyped by the television, the press or the Internet.

However, it is good to know that the Academic Otolaryngology Clinic in St. Louis has embarked upon conducting clinical research studies on the curative aspect of tinnitus and that they have published their views on the topic for the benefit of tinnitus patients, some of which are highlighted below.

The Saint Louis Tinnitus Study - Current Studies On The Topic Include The Use Of Gobapentin In Regard To Providing Relief For The Idiopathic Tinnitus (Subjective) Trial As Per The Following Modes  

  • Objective: To determine the Gobapentin (Neurontin) medicinal in regard to subjective idiopathic tinnitus.

  • Design: Double-blind eight-week indiscriminate medical test.

  • Location: St. Louis Academic Otolaryngology Clinic.

  • Topics: 135 issues with rigorous idiopathic tinnitus (subjective) of six months, or longer than that.

  • Involvement: The drug at continuance dosage covering 900 – 3600 mg/day for eight weeks. Lactose placebo may also be tried.

  • Principal outcome measure: Alteration involving the handicap inventory score of tinnitus starting from the baseline to end (study) point.

  • Results:

    • General change in the handicap inventory score for total cohort from the baseline to the 8th week = 11.2

    • Change involving the 56 people selected at random in regard to the Gobapentin arm =11.3

Change among 56 people in the placebo = 11.00

The Saint Louis Tinnitus Study Conclusion – The Drug Is Equally Ineffective Like The Placebo In Regard To Relief From Idiopathic Subjective Tinnitus

The next study involves the following

The Saint Louis Tinnitus Study – The Academic Otolaryngology Clinic At St. Louis Concerns With (Rtms) Or Repetitive Transcranial Magnetic Stimulation To Provide Relief From Idiopathic Subjective Tinnitus As Detailed Below

Many Americans suffer from tinnitus that is chronic incapacitating subjective while Neuroimaging studies conducted at random have revealed those to be related to hyperactivity of sundry cortical areas, particularly the auditory cortices, plus the middle temporal regions.

rTMS or Repetitive Transcranial Magnetic Stimulation entails application of repeated magnetic spur in the skull  which induces an electro-magnetic field within the brain’s cortical areas that are underlying. However, with low frequency stimulations (1 Hz), the rTMS tends to steer to an increased inhibitory activity in regard to the glutaminergic fibers of the central nervous system. This conclusively proves that rTMS is a newly acquired treatment modality that can be termed as fairly promising for tinnitus victims.

Nevertheless, there will be 3 definite plans to provide appropriate guidance to the project which is detailed below for the benefit of the reader.

  • To ascertain rTMS’s curative value of subjective idiopathic troublesome tinnitus, a lone blind-over fortuitous trial design involving active versus fake rTMS  would be employed. Enrolment will go up to 55 subjects while the size of samples will tend to ensure adequate power to evaluate any clinically significant disparity between the treatments that are defined in terms of a 20-point alteration of the THI score. Several neurocgnitive function tests, carried out before and after the treatment would be done to check if there were more adverse effects in the rTMS as well as executive functioning.

  • To make out the predictors and find out the response factor associated with rTMS treatment for people with acute tinnitus problem. The hypothesis includes several patient factors, clinical features, audiological issues, neurocognitive factors as well as findings in the PET scan at baseline. Also to be considered are changes, if any, concerning these mentioned factors after the rTMS therapy that could be the predictors of the rTMS response.

  • To spot any phenotype (tinnitus patient) that may respond more to rTMS.

This research study, as is expected, will throw valuable light on newer treatment modes for tinnitus, especially the rTMS which appears to be quite promising. However, the results will speak for themselves. But as of now, the best mode of treatment is to not look at the symptoms (as is the case with conventional remedies), but reach out to within the body and identify all the key contributing factors, which can be many. Once these contributing factors have been identified, tinnitus can be effectively treated, and it will never come back again to haunt you.



Saint Louis Tinnitus

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